Description

(R)-2-(3,5-Difluorophenyl)Piperidine is a high-purity chiral piperidine derivative, a crucial building block in modern pharmaceutical research and development. Its core value lies in its role as a versatile intermediate for synthesizing novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology therapeutic areas. This compound is essential for medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries seeking to develop enantiomerically pure drug candidates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and synthesis of novel drug candidates targeting neurological disorders.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural motif in the development of enantiomerically pure APIs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale manufacturing of chiral pharmaceuticals.
• Asymmetric Synthesis: Acts as a chiral ligand precursor or auxiliary in catalytic asymmetric transformations.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(R)-2-(3,5-Difluorophenyl)Piperidine
CAS No.	1213079-50-5
Molecular Formula	C11H13F2N
Molecular Weight	197.22 g/mol
Synonyms	(R)-2-(3,5-Difluorophenyl)piperidine; (R)-3,5-Difluoro-2-piperidin-2-ylbenzene; (R)-2-(3,5-Difluorophenyl)piperidine; (R)-2-Piperidin-2-yl-1,3-difluorobenzene; (R)-2-(3,5-Difluorophenyl)piperidine hydrochloride (salt form); (R)-2-(3,5-Difluorophenyl)piperidine HBr (salt form); 1213079-50-5; (R)-enantiomer of 2-(3,5-Difluorophenyl)piperidine
EINECS	Contact for details

Quality Control

Our (R)-2-(3,5-Difluorophenyl)Piperidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are provided for each lot to guarantee traceability, consistency, and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.