Description

5-((2S)Piperazin-2-Yl)-2-(Trifluoromethyl)Thiophen is a high-value, chiral heterocyclic building block featuring a piperazine ring and a trifluoromethyl-substituted thiophene core. This compound is critical for medicinal chemistry research and development, offering a unique scaffold for modulating the physicochemical and pharmacokinetic properties of drug candidates. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel small-molecule therapeutics.
• Medicinal Chemistry: Used as a privileged scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• API Synthesis: Serves as a critical building block in the multi-step synthesis of potential drug candidates, especially those targeting protease and kinase enzymes.
• Chemical Biology: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective synthesis due to its (2S)-piperazin-2-yl configuration.
• Agrochemical Research: Potential application in the development of advanced crop protection agents with improved efficacy.

Basic Information

Product Name	5-((2S)Piperazin-2-Yl)-2-(Trifluoromethyl)Thiophen
CAS No.	1213052-45-9
Molecular Formula	C9H12F3N3S
Molecular Weight	251.27 g/mol
Synonyms	2-(Trifluoromethyl)-5-[(2S)-piperazin-2-yl]thiophene; (2S)-2-[5-(Trifluoromethyl)thiophen-2-yl]piperazine; 5-[(2S)-Piperazin-2-yl]-2-(trifluoromethyl)thiophene; 2-(Trifluoromethyl)-5-((S)-piperazin-2-yl)thiophene; (S)-2-(5-(Trifluoromethyl)thiophen-2-yl)piperazine; 1213052-45-9; Thiophene, 5-[(2S)-2-piperazinyl]-2-(trifluoromethyl)-; (S)-5-(Piperazin-2-yl)-2-(trifluoromethyl)thiophene
EINECS	Contact for details

Quality Control

Our 5-((2S)Piperazin-2-Yl)-2-(Trifluoromethyl)Thiophen is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.