Description

(3R)-3-[4-(Trifluoromethyl)Phenyl]Morpholine is a high-value chiral morpholine derivative, serving as a critical synthetic intermediate and building block in advanced organic chemistry. Its core value lies in the unique combination of a morpholine scaffold with a chiral center and a trifluoromethylphenyl group, offering significant potential for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, process development, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where the trifluoromethyl group can enhance bioavailability and stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands in asymmetric catalysis or as a structural motif in organocatalysts.
• Material Science: Potential monomer or additive for specialty polymers, where the aromatic and heterocyclic components can influence material properties.
• Chemical Biology Probe Synthesis: Utilized to create molecular probes for studying biological pathways and protein function.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-specific synthesis projects requiring this specific chiral scaffold.

Basic Information

Product Name	(3R)-3-[4-(Trifluoromethyl)Phenyl]Morpholine
CAS No.	1212984-30-9
Molecular Formula	C11H12F3NO
Molecular Weight	231.22 g/mol
Synonyms	(R)-3-(4-(Trifluoromethyl)phenyl)morpholine; (3R)-3-[4-(Trifluoromethyl)phenyl]tetrahydro-2H-1,4-oxazine; (R)-3-(alpha,alpha,α-Trifluoro-p-tolyl)morpholine; 4-[(3R)-Morpholin-3-yl]benzotrifluoride; (R)-4-(Morpholin-3-yl)benzotrifluoride; (R)-3-(4-Trifluoromethylphenyl)morpholine; (R)-3-(p-Trifluoromethylphenyl)morpholine; (R)-3-(4-(Trifluoromethyl)phenyl)morpholine
EINECS	Contact for details

Quality Control

Our (3R)-3-[4-(Trifluoromethyl)Phenyl]Morpholine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) determination by chiral HPLC, chemical purity assay, and identification by spectroscopic methods (NMR, IR, MS). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.