Description

(2S)-2-(2-Chloro-5-Fluorophenyl)Piperidine is a high-purity chiral piperidine derivative, a critical building block in modern pharmaceutical synthesis. Its value lies in its defined stereochemistry and functionalized aromatic ring, which are essential for constructing molecules with specific biological activity. This advanced intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the construction of complex molecules for potential therapeutic applications.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Asymmetric Synthesis: Employed in chiral pool synthesis due to its defined (S)-configuration at the stereocenter.
• Ligand and Catalyst Development: Potential precursor for creating novel chiral ligands or organocatalysts.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(2S)-2-(2-Chloro-5-Fluorophenyl)Piperidine
CAS No.	1212976-31-2
Molecular Formula	C11H13ClFN
Molecular Weight	213.68 g/mol
Synonyms	(S)-2-(2-Chloro-5-fluorophenyl)piperidine; (2S)-2-(2-Chloro-5-fluorophenyl)piperidine; 2-(2-Chloro-5-fluorophenyl)piperidine, (2S)-; 1212976-31-2; (S)-2-(2-Chloro-5-fluorophenyl)piperidine; Piperidine, 2-(2-chloro-5-fluorophenyl)-, (2S)-; (S)-2-(2-Chloro-5-fluoro-phenyl)-piperidine
EINECS	Contact for details

Quality Control

Our (2S)-2-(2-Chloro-5-Fluorophenyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) with full specifications, including enantiomeric excess (ee), is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.