Description

(1S)-1-[1,2,4]Triazolo[4,3-A]Pyridin-3-Ylethanamine CAS NO 1212823-28-3 is a high-purity chiral intermediate featuring a fused triazolopyridine scaffold, a structure of significant interest in modern medicinal chemistry. Its primary value lies in serving as a critical building block for the synthesis of novel, biologically active compounds targeting central nervous system and other therapeutic areas. This advanced intermediate is essential for pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug molecules, particularly in neurological and psychiatric disorders.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the scalable production of candidate drugs containing the triazolopyridine pharmacophore.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Utilized in chiral pool synthesis due to its defined (S)-configuration, facilitating the creation of enantiomerically pure compounds.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis and process development projects.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study biological pathways and target engagement.

Basic Information

Product Name	(1S)-1-[1,2,4]Triazolo[4,3-A]Pyridin-3-Ylethanamine
CAS No.	1212823-28-3
Molecular Formula	C8H10N4
Molecular Weight	162.19 g/mol
Synonyms	(S)-1-(Triazolo[4,3-a]pyridin-3-yl)ethanamine; (1S)-1-(Triazolo[4,3-a]pyridin-3-yl)ethan-1-amine; (S)-1-(1,2,4-Triazolo[4,3-a]pyridin-3-yl)ethanamine; (S)-1-(1,2,4-Triazolo[4,3-a]pyridin-3-yl)ethylamine; (S)-1-(1,2,4-Triazolo[4,3-a]pyridin-3-yl)ethan-1-amine; (S)-1-(1,2,4-Triazolo[4,3-a]pyridin-3-yl)ethanamine hydrochloride (salt form); 1212823-28-3; (S)-Triazolopyridine-ethylamine
EINECS	Contact for details

Quality Control

Our (1S)-1-[1,2,4]Triazolo[4,3-A]Pyridin-3-Ylethanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. Our quality commitment aligns with ICH guidelines for impurities in drug substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.