Description

(1R)-2,2,2-Trifluoro-1-(3-Pyridyl)Ethylamine is a high-purity chiral amine building block of significant interest in advanced organic synthesis. This compound matters because its unique trifluoromethyl and pyridyl groups, combined with its defined stereochemistry, make it a valuable intermediate for creating novel, biologically active molecules. Pharmaceutical and agrochemical R&D teams need it for developing new active ingredients, particularly where fluorine substitution is used to modulate metabolic stability, lipophilicity, and binding affinity.

Application

• As a key chiral intermediate in the synthesis of pharmaceutical candidates, especially in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Utilized in the research and development of agrochemicals, where the trifluoromethyl group can enhance herbicidal or insecticidal activity.
• Serves as a specialized building block for ligand and catalyst design in asymmetric synthesis.
• Used in the preparation of fluorinated analogs of existing drug molecules to study structure-activity relationships (SAR).
• Potential application in the synthesis of advanced materials, such as liquid crystals or organic semiconductors, due to its aromatic and fluorinated structure.

Basic Information

Product Name	(1R)-2,2,2-Trifluoro-1-(3-Pyridyl)Ethylamine
CAS No.	1212813-98-3
Molecular Formula	C7H7F3N2
Molecular Weight	176.14 g/mol
Synonyms	(R)-1-(3-Pyridyl)-2,2,2-trifluoroethylamine; (1R)-1-(Pyridin-3-yl)-2,2,2-trifluoroethanamine; (R)-α-(Trifluoromethyl)-3-pyridinemethanamine; (R)-3-(1-Amino-2,2,2-trifluoroethyl)pyridine; (R)-TFMPA; (R)-Trifluoromethylpyridylethylamine; (R)-TFE-3-Pyridine
EINECS	Contact for details

Quality Control

Our (1R)-2,2,2-Trifluoro-1-(3-Pyridyl)Ethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral excess, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.