Description

(R)-Hexahydro-Oxazolo[3,4-A]Pyrazin-3-One Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant interest in modern organic synthesis. This compound matters for its role as a key precursor in the development of novel therapeutic agents, particularly those targeting the central nervous system. Pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers need this material for constructing complex molecular architectures with high stereochemical fidelity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Asymmetric Synthesis: Used as a starting material or reagent in catalytic asymmetric reactions to introduce specific stereocenters.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs for new chemical entities.
• Peptidomimetic Scaffold Development: Serves as a constrained, heterocyclic scaffold to mimic peptide secondary structures in drug design.
• Academic & Industrial R&D: Utilized in chemical biology and methodology development research within university and corporate laboratories.
• Custom Synthesis: A building block for the contract manufacturing of proprietary compounds and advanced intermediates.

Basic Information

Product Name	(R)-Hexahydro-Oxazolo[3,4-A]Pyrazin-3-One Hydrochloride
CAS No.	1212327-95-1
Molecular Formula	C7H12ClN3O2
Molecular Weight	205.64 g/mol
Synonyms	(3R)-Hexahydro-1H,3H-oxazolo[3,4-a]pyrazin-3-one hydrochloride; (R)-1,2,3,6,7,8-Hexahydrooxazolo[3,4-a]pyrazin-3-one HCl; (R)-HOP-HCl; (R)-Oxazolo[3,4-a]pyrazin-3-one, hexahydro-, hydrochloride; (R)-1,2,3,6,7,8-Hexahydro-oxazolo[3,4-a]pyrazin-3-one hydrochloride; CAS 1212327-95-1
EINECS	Contact for details

Quality Control

Our (R)-Hexahydro-Oxazolo[3,4-A]Pyrazin-3-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are provided to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under anhydrous conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.