Description

(2R,3R)-1-(2-Methoxyethyl)-2-(3-Methyl-2-Thienyl)-6-Oxopiperidine-3-Carboxylic Acid is a high-purity, chiral piperidine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or building block for the creation of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of novel drug candidates, especially for central nervous system (CNS) or metabolic disorder targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new therapeutic molecules.
• Process Chemistry Development: Serves as a reference standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized in reactions that construct complex molecular architectures with high enantiomeric purity.
• Chemical Biology Probes: Potential use in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis Projects: Supplied to clients requiring bespoke, high-complexity intermediates for proprietary research programs.

Basic Information

Product Name	(2R,3R)-1-(2-Methoxyethyl)-2-(3-Methyl-2-Thienyl)-6-Oxopiperidine-3-Carboxylic Acid
CAS No.	1212305-26-4
Molecular Formula	C14H19NO4S
Molecular Weight	297.37 g/mol
Synonyms	(2R,3R)-1-(2-Methoxyethyl)-2-(3-methylthiophen-2-yl)-6-oxopiperidine-3-carboxylic acid; 6-Oxo-1-(2-methoxyethyl)-2-(3-methyl-2-thienyl)piperidine-3-carboxylic acid, (2R,3R)-; (2R,3R)-2-(3-Methyl-2-thienyl)-1-(2-methoxyethyl)-6-oxo-3-piperidinecarboxylic acid; (2R,3R)-rel-1-(2-Methoxyethyl)-2-(3-methyl-2-thienyl)-6-oxopiperidine-3-carboxylic Acid; (2R,3R)-1-(2-Methoxyethyl)-2-(3-methyl-2-thienyl)piperidine-3,6-dicarboxylic acid 6-ethyl ester (related ester); CAS 1212305-26-4
EINECS	Contact for details

Quality Control

Our (2R,3R)-1-(2-Methoxyethyl)-2-(3-Methyl-2-Thienyl)-6-Oxopiperidine-3-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, suitable for demanding research applications. We provide comprehensive analytical data including HPLC purity, chiral purity, and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are available upon request for every batch shipped.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.