Description

(S)-Piperazine-2-Carbonitrile is a high-value, chiral piperazine derivative that serves as a critical building block in modern organic synthesis. Its enantiopure structure is essential for creating compounds with specific stereochemical configurations, directly impacting biological activity and material properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and production of enantiomerically pure pesticides and herbicides, where stereochemistry is crucial for efficacy and environmental safety.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to achieve high enantioselectivity.
• Chemical Biology & Proteomics: Employed as a building block for designing molecular probes and activity-based protein profiling (ABPP) agents to study enzyme function.
• Material Science Research: Investigated for the synthesis of specialized polymers and functionalized materials with tailored chiral properties.

Basic Information

Product Name	(S)-Piperazine-2-Carbonitrile
CAS No.	1212303-37-1
Molecular Formula	C5H9N3
Molecular Weight	111.15 g/mol
Synonyms	(S)-2-Cyanopiperazine; (2S)-Piperazine-2-carbonitrile; (S)-2-Piperazinecarbonitrile; (S)-Piperazine-2-carbonitrile; (S)-Tetrahydro-2-pyrazinecarbonitrile; (S)-1,4-Diazacyclohexane-2-carbonitrile; (S)-2-Cyano-piperazine
EINECS	Contact for details

Quality Control

Our (S)-Piperazine-2-Carbonitrile is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess (ee).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.