Description

(Cis)-3-(tert-Butoxycarbonyl)Cyclobutanecarboxylic Acid is a high-purity, protected cyclobutane derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, four-membered ring scaffold with orthogonal protecting groups, enabling precise stereochemical control in complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for applications requiring constrained geometries.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, including protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides where the cyclobutane ring confers unique biological activity and stability.
• Material Science: Serves as a precursor for specialty polymers and liquid crystals that benefit from the incorporation of rigid, alicyclic structures.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tools to study enzyme mechanisms and protein-ligand interactions.
• Asymmetric Catalysis: Utilized as a substrate or ligand precursor in the development of new catalytic systems for stereoselective transformations.

Basic Information

Product Name	(Cis)-3-(tert-Butoxycarbonyl)Cyclobutanecarboxylic Acid
CAS No.	1212288-54-4
Molecular Formula	C10H16O4
Molecular Weight	200.23 g/mol
Synonyms	cis-3-[(tert-Butoxy)carbonyl]cyclobutanecarboxylic Acid; (1r,3s)-3-(tert-Butoxycarbonyl)cyclobutanecarboxylic Acid; (1s,3r)-3-(tert-Butoxycarbonyl)cyclobutanecarboxylic Acid; cis-3-(Boc)Cyclobutanecarboxylic Acid; (1r,3s)-3-(Boc)Cyclobutanecarboxylic Acid; Boc-Cyclobutane-cis-3-carboxylic Acid; 3-(tert-Butoxycarbonyl)cyclobutanecarboxylic Acid, cis-; Cyclobutanecarboxylic acid, 3-[(1,1-dimethylethoxy)carbonyl]-, cis-
EINECS	Contact for details

Quality Control

Our (Cis)-3-(tert-Butoxycarbonyl)Cyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.