Description

(1R,3R,5R)-Rel-2-Azabicyclo[3.1.0]Hexane-3-Carboxylic Acid Hydrochloride is a high-purity, stereochemically defined bicyclic proline derivative and a key chiral building block in pharmaceutical synthesis. Its rigid, constrained structure is crucial for developing novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and target selectivity. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process development of peptide mimetics, protease inhibitors, and other advanced therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug candidates, particularly in medicinal chemistry programs.
• Peptidomimetic Scaffold: Used to construct conformationally restricted peptide analogs to improve bioavailability and receptor binding affinity.
• Protease Inhibitor Development: Serves as a core structural element in the design of inhibitors for various enzymatic targets.
• Chemical Biology Research: Employed as a tool compound for studying protein-ligand interactions and structure-activity relationships (SAR).
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and cGMP manufacturing of clinical trial materials.
• Academic Research: Used in university laboratories for methodological development in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	(1R,3R,5R)-Rel-2-Azabicyclo[3.1.0]Hexane-3-Carboxylic Acid Hydrochloride
CAS No.	1212157-09-9
Molecular Formula	C7H10ClNO2
Molecular Weight	175.61 g/mol
Synonyms	(1R,3R,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid hydrochloride; rel-(1R,3R,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid hydrochloride; (1R,3R,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid HCl; Bicycloproline hydrochloride; 2-Aza-bicyclo[3.1.0]hexane-3-carboxylic acid hydrochloride (rel-(1R,3R,5R)-form); Constrained proline derivative hydrochloride
EINECS	Contact for details

Quality Control

Our (1R,3R,5R)-Rel-2-Azabicyclo[3.1.0]Hexane-3-Carboxylic Acid Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. We employ advanced analytical techniques including HPLC, NMR, and chiral analysis to verify identity, potency, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% e.e.
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.