Description

4-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Picolinic Acid is a high-purity, protected piperazine-picolinic acid derivative that serves as a critical building block in modern organic synthesis. Its primary value lies in its role as a versatile intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs), especially within therapeutic areas requiring sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in oncology, CNS disorders, and anti-infective research.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in constructing linkers and ligands for targeted protein degradation platforms.
• Peptidomimetic Chemistry: Facilitates the introduction of rigid, functionalized piperazine scaffolds into peptide-like structures to enhance stability and bioavailability.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and protein-protein interactions.
• Agrochemical Research: Serves as a precursor for developing new crop protection agents with novel modes of action.
• Material Science: Potential use as a monomer or functional additive in the synthesis of advanced polymers with specific ligand-binding properties.

Basic Information

Product Name	4-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Picolinic Acid
CAS No.	1211595-81-1
Molecular Formula	C15H21N3O4
Molecular Weight	307.35 g/mol
Synonyms	4-[4-[(2-Methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]pyridine-2-carboxylic acid; 4-(4-Boc-piperazin-1-yl)picolinic acid; 1-Boc-4-(2-carboxypyridin-4-yl)piperazine; 4-(N-Boc-piperazinyl)-2-pyridinecarboxylic acid; 4-(1-Boc-4-piperazinyl)-2-pyridinecarboxylic acid; 2-Pyridinecarboxylic acid, 4-[4-[[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]-; 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyridine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Picolinic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment. We support development from discovery through to pre-clinical stages with consistent quality and full traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.