Description

(4-Trifluoromethyl-Piperidin-4-Yl)-Carbamic Acid tert-Butyl Ester is a high-value, protected amine building block essential for modern pharmaceutical and agrochemical research. This compound is specifically designed to introduce a trifluoromethyl-substituted piperidine scaffold, a privileged structure known to enhance metabolic stability, lipophilicity, and bioavailability in active molecules. It is a critical intermediate for medicinal chemists and process development scientists working on novel drug candidates, particularly in CNS, oncology, and anti-infective therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs) targeting G-protein-coupled receptors (GPCRs) and kinases.
• Agrochemical Research: Used in developing advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves compound efficacy and environmental stability.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and tool compounds to study biological pathways and enzyme functions.
• Peptidomimetics: Incorporated into peptide backbones to create metabolically stable analogs with enhanced pharmacological properties.
• Material Science: Potential monomer or additive for specialty polymers where fluorine content can alter surface properties and chemical resistance.

Basic Information

Product Name	(4-Trifluoromethyl-Piperidin-4-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	1211583-41-3
Molecular Formula	C11H19F3N2O2
Molecular Weight	268.28 g/mol
Synonyms	tert-Butyl N-(4-trifluoromethyl-4-piperidyl)carbamate; 4-[(tert-Butoxycarbonyl)amino]-4-(trifluoromethyl)piperidine; 1-Boc-4-amino-4-trifluoromethylpiperidine; 4-(Boc-amino)-4-(trifluoromethyl)piperidine; 4-(Trifluoromethyl)piperidin-4-amine, N-Boc-protected; BOC-4-Amino-4-trifluoromethylpiperidine; N-Boc-4-Amino-4-trifluoromethylpiperidine
EINECS	Contact for details

Quality Control

Every batch of (4-Trifluoromethyl-Piperidin-4-Yl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes comprehensive analysis by HPLC, NMR, and MS to meet the exacting requirements of research and development. Certificates of Analysis (COA) with full analytical data are provided for each lot, and custom synthesis to specific purity grades (e.g., >98%, >99%) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.