Description

6-Chloro-2-Fluoro Nicotinic Acid is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, enabling precise molecular modifications. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating new compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the chloro-fluoro substitution pattern is valuable for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized organic materials and polymers with specific electronic or photonic properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects for clients.

Basic Information

Product Name	6-Chloro-2-Fluoro Nicotinic Acid
CAS No.	1211578-46-9
Molecular Formula	C6H3ClFNO2
Molecular Weight	175.55 g/mol
Synonyms	2-Fluoro-6-chloronicotinic acid; 6-Chloro-2-fluoropyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 6-chloro-2-fluoro-; Nicotinic acid, 6-chloro-2-fluoro-; 6-Chloro-2-fluoro-3-pyridinecarboxylic acid; 2-Fluoro-6-chloro-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 6-Chloro-2-Fluoro Nicotinic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.