Description

1-Piperazinecarboxylic Acid, 4-(4-Piperidinylmethyl)-, 1,1-Dimethylethyl Ester is a high-value, protected piperazine-piperidine hybrid building block designed for advanced pharmaceutical research and development. This compound is critical for medicinal chemists seeking to introduce complex, nitrogen-rich pharmacophores into novel drug candidates, particularly in central nervous system (CNS) and oncology targets. It is primarily utilized by R&D laboratories and fine chemical manufacturers engaged in the synthesis of sophisticated active pharmaceutical ingredients (APIs) and chemical probes.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug molecules, especially those targeting neurological receptors (e.g., GPCRs) and kinases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in structure-activity relationship (SAR) studies and high-throughput screening (HTS) campaigns.
• API Development: Used in the development and scale-up of new Active Pharmaceutical Ingredients (APIs) requiring a bifunctional piperazine-piperidine moiety.
• Chemical Biology: Employed in the synthesis of labeled compounds or chemical probes for target identification and validation studies.
• Process Chemistry: Acts as a protected intermediate in the development of robust and scalable commercial manufacturing routes for final drug substances.

Basic Information

Product Name	1-Piperazinecarboxylic Acid, 4-(4-Piperidinylmethyl)-, 1,1-Dimethylethyl Ester
CAS No.	1211568-27-2
Molecular Formula	C16H30N2O2
Molecular Weight	282.43 g/mol
Synonyms	tert-Butyl 4-(piperidin-4-ylmethyl)piperazine-1-carboxylate; 4-(Piperidin-4-ylmethyl)piperazine-1-carboxylic acid tert-butyl ester; 1-Boc-4-(4-piperidinylmethyl)piperazine; N-Boc-4-(4-piperidinylmethyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(4-piperidinylmethyl)piperazine; 4-(Piperidin-4-ylmethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1-Piperazinecarboxylic Acid, 4-(4-Piperidinylmethyl)-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.