Description

tert-Butyl 4-(5-Hydroxypyridin-2-yl)piperazine-1-carboxylate is a high-purity, protected piperazine-pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile, functionalized scaffold for constructing complex molecules with precise pharmacological properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating targeted libraries and developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the synthesis of advanced crop protection agents and herbicides, leveraging its heterocyclic structure.
• Chemical Biology Probe Development: Serves as a core structure for creating molecular probes to study biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring functionalized piperazine chemistry.
• Academic & Institutional Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and hit-to-lead optimization.

Basic Information

Product Name	tert-Butyl 4-(5-Hydroxypyridin-2-yl)piperazine-1-carboxylate
CAS No.	1211542-18-5
Molecular Formula	C14H21N3O3
Molecular Weight	279.34 g/mol
Synonyms	2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-5-hydroxypyridine; 1-Boc-4-(5-hydroxy-2-pyridyl)piperazine; tert-Butyl 4-(5-hydroxy-2-pyridinyl)-1-piperazinecarboxylate; 5-Hydroxy-2-(1-piperazinyl)pyridine 1-Boc derivative; BOC-4-(5-Hydroxy-pyridin-2-yl)-piperazine; 1211542-18-5; 2-Piperazin-1-yl-pyridin-5-ol, N-Boc protected
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(5-Hydroxypyridin-2-yl)piperazine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.