Description

1H-Cyclopenta[B]Pyrazine-1-Carboxylic Acid, Octahydro-, 1,1-Dimethylethyl Ester is a high-purity, protected amino acid derivative serving as a critical chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures with precise stereochemistry, enabling the development of novel active pharmaceutical ingredients (APIs). Pharmaceutical R&D and fine chemical synthesis professionals need it for creating peptide mimetics, heterocyclic compounds, and other sophisticated intermediates where structural integrity and purity are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetic Synthesis: Used to introduce constrained, bicyclic proline-like structures into peptide chains to enhance metabolic stability and receptor selectivity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts.
• Agrochemical Research: Employed in the discovery of new, biologically active compounds with specific stereochemical requirements.
• Academic & Institutional Research: A valuable tool for methodological studies in organic chemistry, particularly in stereoselective synthesis and heterocycle chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	1H-Cyclopenta[B]Pyrazine-1-Carboxylic Acid, Octahydro-, 1,1-Dimethylethyl Ester
CAS No.	1211539-11-5
Molecular Formula	C12H20N2O2
Molecular Weight	224.30 g/mol
Synonyms	tert-Butyl octahydro-1H-cyclopenta[b]pyrazine-1-carboxylate; (1S,3aS,6aR)-tert-Butyl octahydro-1H-cyclopenta[b]pyrazine-1-carboxylate; (3aS,6aR)-tert-Butyl octahydro-1H-cyclopenta[b]pyrazine-1-carboxylate; 1-Boc-octahydrocyclopenta[b]pyrazine; Octahydro-1H-cyclopenta[b]pyrazine-1-carboxylic acid 1,1-dimethylethyl ester; Bicyclic Proline Derivative Boc-Protected; tert-Butyl (3aS,6aR)-octahydro-1H-cyclopenta[b]pyrazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our production of 1H-Cyclopenta[B]Pyrazine-1-Carboxylic Acid, Octahydro-, 1,1-Dimethylethyl Ester adheres to stringent internal quality standards, ensuring batch-to-batch consistency for research and development applications. All materials undergo comprehensive analytical characterization, including chiral purity verification, to meet the exacting requirements of advanced synthetic chemistry. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.