Description

6-Cyano-2-(Trifluoromethyl)Nicotinic Acid is a high-value, multi-functional heterocyclic building block characterized by its cyano and trifluoromethyl substituents. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and bioactivity.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials and liquid crystals due to its electron-withdrawing groups.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	6-Cyano-2-(Trifluoromethyl)Nicotinic Acid
CAS No.	1211537-27-7
Molecular Formula	C8H3F3N2O2
Molecular Weight	216.12 g/mol
Synonyms	2-(Trifluoromethyl)-6-cyanonicotinic acid; 6-Cyano-2-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 6-cyano-2-(trifluoromethyl)-; Nicotinic acid, 6-cyano-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 6-Cyano-2-(Trifluoromethyl)Nicotinic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product should be kept under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.