Description

2-Amino-4,5-Difluoropyridine is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in the strategic placement of fluorine atoms and an amino group on the pyridine ring, enabling precise molecular modifications for creating novel compounds with targeted properties. This intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoro-amino-pyridine moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for constructing sophisticated nitrogen-containing ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or fluorinated polymers, due to its electron-deficient aromatic system.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the fine chemical market.

Basic Information

Product Name	2-Amino-4,5-Difluoropyridine
CAS No.	1211537-08-4
Molecular Formula	C5H4F2N2
Molecular Weight	130.10 g/mol
Synonyms	4,5-Difluoropyridin-2-amine; 4,5-Difluoro-2-pyridinamine; 2-Pyridinamine, 4,5-difluoro-; 4,5-Difluoro-2-aminopyridine; 2-Amino-4,5-difluoropyridine; 4,5-Difluoro-2-pyridylamine; 2-Amino-4,5-difluoro-pyridine
EINECS	Contact for details

Quality Control

Our 2-Amino-4,5-Difluoropyridine is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization and impurity profiling. A Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with each shipment. Our quality commitment supports compliance with ISO standards and meets the rigorous demands of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.