Description

5-Bromo-3-cyclopropyl-1H-pyrazolo[3,4-b]pyridine is a high-purity, advanced pharmaceutical intermediate and heterocyclic building block. This compound is valued for its unique fused bicyclic structure, which is critical for modulating biological activity in drug discovery programs. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly kinase inhibitors and other small molecule drugs targeting various disease pathways.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Scaffold: Serves as a core structural motif for designing potent and selective kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies to optimize drug candidate properties.
• Chemical Biology Probes: Employed in the synthesis of tool compounds for investigating biological pathways and target validation.
• Custom Synthesis Building Block: Supplied for contract research organizations (CROs) and CDMOs requiring specialized heterocyclic fragments.
• Agrochemical Research: Potential application as an intermediate in the discovery of novel crop protection agents.

Basic Information

Product Name	5-Bromo-3-cyclopropyl-1H-pyrazolo[3,4-b]pyridine
CAS No.	1211537-03-9
Molecular Formula	C9H8BrN3
Molecular Weight	238.09 g/mol
Synonyms	3-Cyclopropyl-5-bromo-1H-pyrazolo[3,4-b]pyridine; 5-Bromo-3-cyclopropyl-1H-pyrazolo[3,4-b]pyridine; 1H-Pyrazolo[3,4-b]pyridine, 5-bromo-3-cyclopropyl-; 5-Bromo-3-cyclopropyl-pyrazolo[3,4-b]pyridine; 5-Bromo-3-cyclopropyl-1H-pyrazolo[3,4-b]pyridine; 1211537-03-9; 5-Br-3-CPP
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-cyclopropyl-1H-pyrazolo[3,4-b]pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.