Description

Methyl 3-Bromo-5-(Trifluoromethyl)-2-Pyridinecarboxylate is a high-value, multi-functional pyridine derivative and a crucial synthetic intermediate in advanced organic chemistry. Its core value lies in the strategic combination of bromine and trifluoromethyl substituents, which provide distinct reactivity and lipophilicity for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form new carbon-carbon bonds.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to explore and optimize the bioactivity of lead compounds.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis services and contract research organizations (CROs/CMOs) developing proprietary compounds for clients.

Basic Information

Product Name	Methyl 3-Bromo-5-(Trifluoromethyl)-2-Pyridinecarboxylate
CAS No.	1211536-14-9
Molecular Formula	C8H5BrF3NO2
Molecular Weight	284.03 g/mol
Synonyms	3-Bromo-5-(trifluoromethyl)picolinic acid methyl ester; Methyl 3-bromo-5-(trifluoromethyl)picolinate; 2-Pyridinecarboxylic acid, 3-bromo-5-(trifluoromethyl)-, methyl ester; 3-Bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-Bromo-5-(Trifluoromethyl)-2-Pyridinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.