Description

5-Bromo-Pyrazine-2-Carbaldehyde is a versatile and high-purity brominated heterocyclic building block essential for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise molecular modifications to develop novel active compounds. It is primarily used by the pharmaceutical, agrochemical, and material science industries for applications in drug discovery, ligand synthesis, and the creation of functionalized pyrazine derivatives.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides by providing a reactive site for further functionalization.
• Ligand Synthesis: Serves as a crucial starting material for constructing complex chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of organic electronic materials, such as conductive polymers and molecular semiconductors.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Chemical Biology Probes: Utilized to create labeled compounds and molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	5-Bromo-Pyrazine-2-Carbaldehyde
CAS No.	1211534-08-5
Molecular Formula	C5H3BrN2O
Molecular Weight	186.99 g/mol
Synonyms	5-Bromo-2-pyrazinecarboxaldehyde; 5-Bromopyrazine-2-carboxaldehyde; 2-Pyrazinecarboxaldehyde, 5-bromo-; 5-Bromo-2-formylpyrazine; 5-Bromopyrazinecarbaldehyde; 1211534-08-5; 5-Bromo-2-pyrazinecarbaldehyde
EINECS	Contact for details

Quality Control

Our 5-Bromo-Pyrazine-2-Carbaldehyde is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to verify identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We adhere to cGMP standards where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.