Description

6-Chloro-5-Hydroxypyridine-3-Carboxylic Acid is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound serves as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique substitution pattern enables precise molecular construction. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of functional organic materials, such as metal-organic frameworks (MOFs) and electronic chemicals.
• Chemical Biology Probes: Utilized as a building block for synthesizing molecular probes to study biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	6-Chloro-5-Hydroxypyridine-3-Carboxylic Acid
CAS No.	1211531-26-8
Molecular Formula	C6H4ClNO3
Molecular Weight	173.55 g/mol
Synonyms	5-Hydroxy-6-chloronicotinic acid; 3-Carboxy-6-chloro-5-hydroxypyridine; 6-Chloro-5-hydroxynicotinic acid; 6-Chloro-5-hydroxy-3-pyridinecarboxylic acid; 6-Chloro-5-hydroxypyridine-3-carboxylic acid; 6-Chloro-5-pyridinol-3-carboxylic acid; 1211531-26-8
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-5-Hydroxypyridine-3-Carboxylic Acid is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for research and commercial synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as confirmed by HPLC, NMR, and MS. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to structure
Identification (IR)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.