Description

5-Methyl-2-(Piperazin-1-Yl)Benzonitrile is a high-purity, advanced pharmaceutical intermediate featuring a benzonitrile core substituted with a methyl group and a piperazine ring. This molecular architecture makes it a critical building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent drug candidates, especially those targeting neurological receptors.
• CNS Drug Development: Used in research for creating potential antipsychotic, antidepressant, and anxiolytic compounds due to the piperazine pharmacophore.
• Oncology Research: Serves as a scaffold for developing kinase inhibitors and other targeted cancer therapies.
• Chemical Biology & Proteomics: Employed as a tool compound or a building block for chemical probes to study biological pathways.
• Agrochemical Synthesis: Can be utilized in the development of novel herbicides or fungicides requiring specific nitrogen-containing heterocycles.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced organic materials.

Basic Information

Product Name	5-Methyl-2-(Piperazin-1-Yl)Benzonitrile
CAS No.	1211529-31-5
Molecular Formula	C₁₂H₁₅N₃
Molecular Weight	201.27 g/mol
Synonyms	2-(1-Piperazinyl)-5-methylbenzonitrile; 5-Methyl-2-piperazin-1-ylbenzonitrile; 2-Piperazin-1-yl-5-methylbenzonitrile; Benzonitrile, 5-methyl-2-(1-piperazinyl)-; 1211529-31-5; 5-Methyl-2-(piperazin-1-yl)benzonitrile; 2-(Piperazin-1-yl)-5-methylbenzonitrile
EINECS	Contact for details

Quality Control

Our 5-Methyl-2-(Piperazin-1-Yl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.