Description

2-Bromo-3-Chloro-5-Methoxypyridine is a high-purity halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which provides versatile reactivity for constructing complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drug candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Chemical Biology & Proteomics: Employed as a versatile scaffold or labeling reagent in the design of molecular probes and enzyme inhibitors.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create complex biaryl and heteroaryl systems.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Bromo-3-Chloro-5-Methoxypyridine
CAS No.	1211525-38-0
Molecular Formula	C6H5BrClNO
Molecular Weight	222.47 g/mol
Synonyms	3-Chloro-2-bromo-5-methoxypyridine; 5-Methoxy-2-bromo-3-chloropyridine; 2-Bromo-3-chloro-5-methoxypyridine; Pyridine, 2-bromo-3-chloro-5-methoxy-; 1211525-38-0
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Chloro-5-Methoxypyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Handle and store in accordance with all applicable local and international regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.