Description

3-Bromo-2-(Difluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative serving as a critical building block in advanced chemical synthesis. Its unique structure, featuring both bromine and difluoromethyl substituents, enables precise molecular modifications essential for developing novel compounds with targeted properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), due to its electron-deficient pyridine core.
• Fluorine Chemistry Building Block: The difluoromethyl moiety makes it a valuable reagent for introducing fluorine atoms into complex molecules, a common strategy in modern medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated pyridine frameworks.

Basic Information

Product Name	3-Bromo-2-(Difluoromethyl)Pyridine
CAS No.	1211520-77-2
Molecular Formula	C6H4BrF2N
Molecular Weight	207.99 g/mol
Synonyms	2-(Difluoromethyl)-3-bromopyridine; 3-Bromo-2-(difluoromethyl)pyridine; Pyridine, 3-bromo-2-(difluoromethyl)-; 3-Bromo-2-difluoromethylpyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-(Difluoromethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in regulated environments, including cGMP for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.