Description

6-Methoxy-5-(Trifluoromethyl)Nicotinaldehyde is a high-value, multi-functional chemical building block characterized by its unique trifluoromethyl and aldehyde functional groups on a nicotinic acid derivative scaffold. This compound is essential for the synthesis of complex molecules, offering significant advantages in modulating the physicochemical and metabolic properties of target compounds. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients. Its structural features make it a critical intermediate in medicinal chemistry programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry for CNS, oncology, and anti-infective research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials and advanced polymers due to its electron-withdrawing substituents.
• Chemical Biology Probes: Utilized to create labeled compounds and molecular probes for studying biological mechanisms and target engagement.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	6-Methoxy-5-(Trifluoromethyl)Nicotinaldehyde
CAS No.	1211519-38-8
Molecular Formula	C8H6F3NO2
Molecular Weight	205.14 g/mol
Synonyms	5-(Trifluoromethyl)-6-methoxynicotinaldehyde; 6-Methoxy-5-(trifluoromethyl)pyridine-3-carbaldehyde; 3-Pyridinecarboxaldehyde, 6-methoxy-5-(trifluoromethyl)-; 6-Methoxy-5-trifluoromethylnicotinaldehyde; 6-Methoxy-5-trifluoromethyl-3-pyridinecarboxaldehyde; Aldehyde C8H6F3NO2 (1211519-38-8)
EINECS	Contact for details

Quality Control

Our 6-Methoxy-5-(Trifluoromethyl)Nicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to cGMP principles and stringent in-process controls guarantees a reliable supply of this high-purity intermediate for critical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity, the container should be kept under an inert atmosphere (e.g., nitrogen) to prevent oxidation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.