Description

tert-Butyl 4-(Methylthio)-3-Iodopyridin-2-Ylcarbamate is a high-value, multi-functional pyridine derivative designed for advanced synthetic chemistry. This compound serves as a critical building block in pharmaceutical research and development, offering versatile reactivity for constructing complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its halogen and sulfur functionalities.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to form new carbon-carbon bonds.
• Functional Group Manipulation: The tert-butyl carbamate (Boc) protecting group and methylthio moiety allow for selective deprotection and further functionalization, enabling complex synthetic pathways.
• Ligand and Catalyst Development: Serves as a starting material for the synthesis of specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Investigated as a monomer or building block for creating novel organic electronic materials and polymers.

Basic Information

Product Name	tert-Butyl 4-(Methylthio)-3-Iodopyridin-2-Ylcarbamate
CAS No.	1211504-19-6
Molecular Formula	C11H15IN2O2S
Molecular Weight	366.22 g/mol
Synonyms	tert-Butyl N-[4-(methylsulfanyl)-3-iodopyridin-2-yl]carbamate; 2-Pyridinecarboxamide, N-[4-(methylthio)-3-iodo-2-pyridinyl]-, 1,1-dimethylethyl ester; 4-(Methylthio)-3-iodopyridin-2-amine, N-Boc protected; Boc-4-(Methylthio)-3-iodo-2-aminopyridine; 3-Iodo-4-(methylthio)pyridin-2-ylcarbamic acid tert-butyl ester; tert-Butyl (4-(methylthio)-3-iodopyridin-2-yl)carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Methylthio)-3-Iodopyridin-2-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP standards where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.