Description

(S)-n-1-Boc-4-Cbz-2-Piperazinecarboxylic Acid Methyl Ester is a high-purity, chiral piperazine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a protected, stereochemically defined scaffold for constructing complex molecules with high precision. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and other fine chemicals where chirality is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including protease inhibitors, kinase inhibitors, and other small molecule drugs.
• Peptidomimetic Chemistry: Used to introduce constrained piperazine motifs into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• Asymmetric Synthesis: Serves as a versatile starting material or intermediate in stereoselective synthesis routes for complex natural products and bioactive compounds.
• Agrochemical Research: Employed in the development of new chiral pesticides and herbicides where specific stereochemistry influences biological activity.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental component for custom synthesis organizations (CSOs) producing bespoke compounds for client R&D programs.

Basic Information

Product Name	(S)-n-1-Boc-4-Cbz-2-Piperazinecarboxylic Acid Methyl Ester
CAS No.	1211399-66-4
Molecular Formula	C19H26N2O6
Molecular Weight	378.42 g/mol
Synonyms	(S)-1-Boc-4-Cbz-2-piperazinecarboxylic acid methyl ester; Methyl (S)-1-(tert-butoxycarbonyl)-4-(benzyloxycarbonyl)piperazine-2-carboxylate; (S)-1-N-Boc-4-N-Cbz-piperazine-2-carboxylic acid methyl ester; (S)-Methyl 1-Boc-4-Cbz-piperazine-2-carboxylate; (S)-Piperazine-2-carboxylic acid, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, methyl ester; Boc-Cbz-(S)-piperazine-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our (S)-n-1-Boc-4-Cbz-2-Piperazinecarboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.