Description

3-Bromo-2,5-difluoropyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, offers versatile reactivity for selective cross-coupling and nucleophilic substitution reactions, enabling the precise construction of complex molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing difluoropyridine or aryl bromide motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized nitrogen-containing ligands used in transition metal catalysis.
• Material Science: Employed in the synthesis of organic electronic materials, such as those for OLEDs or conductive polymers, due to its electron-deficient aromatic system.
• Chemical Research: A versatile reagent for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Fluorine Chemistry: The fluorine atoms provide sites for further functionalization, making it valuable for developing compounds with tailored physicochemical properties.

Basic Information

Product Name	3-Bromo-2,5-difluoropyridine
CAS No.	1211331-43-9
Molecular Formula	C5H2BrF2N
Molecular Weight	193.98 g/mol
Synonyms	2,5-Difluoro-3-bromopyridine; 3-Bromo-2,5-difluoropyridine; Pyridine, 3-bromo-2,5-difluoro-; 1211331-43-9; 3-Br-2,5-F2Py; 3-Bromo-2,5-difluoro-pyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-2,5-difluoropyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring high-purity intermediates for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Typical 98-99%)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.