Description

Piperazine, 1-(3-Thienylmethyl)-, Dihydrochloride is a specialized heterocyclic building block and salt derivative of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its piperazine-thiophene hybrid structure offers unique pharmacophoric properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, or as kinase inhibitors.
• Agrochemical Research: Used in the development of new pesticides, herbicides, or fungicides where the piperazine moiety can modulate biological activity and physicochemical properties.
• Chemical Biology & Proteomics: Serves as a scaffold or linker in the design of chemical probes, enzyme inhibitors, or affinity purification reagents.
• Material Science Precursor: Potential use in the synthesis of functionalized polymers, ligands for catalysis, or organic electronic materials.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) laboratories for method development and exploratory synthetic chemistry projects.

Basic Information

Product Name	Piperazine, 1-(3-Thienylmethyl)-, Dihydrochloride
CAS No.	1211256-64-2
Molecular Formula	C9H14N2S · 2HCl
Molecular Weight	267.21 g/mol (for dihydrochloride salt)
Synonyms	1-[(Thiophen-3-yl)methyl]piperazine Dihydrochloride; 1-(3-Thienylmethyl)piperazine Dihydrochloride; 3-[(Piperazin-1-yl)methyl]thiophene Dihydrochloride; 1-(Thiophen-3-ylmethyl)piperazine Dihydrochloride; N-(3-Thienylmethyl)piperazine Dihydrochloride; Piperazine, 1-[(3-thienyl)methyl]-, dihydrochloride; (3-Thienylmethyl)piperazine Dihydrochloride
EINECS	Contact for details

Quality Control

Our Piperazine, 1-(3-Thienylmethyl)-, Dihydrochloride is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.