Description

1-Piperidinecarboxylic Acid, 3,3-Difluoro-4-Hydroxy-, 1,1-Dimethylethyl Ester is a high-value, fluorinated piperidine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, particularly in the creation of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce fluorine atoms and the tert-butyloxycarbonyl (Boc) protecting group.
• Peptidomimetic Synthesis: Employed in the construction of peptide analogs where the fluorinated piperidine moiety mimics natural amino acid structures.
• Agrochemical Development: Acts as a precursor in the synthesis of advanced crop protection agents with improved efficacy.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects requiring specialized fluorinated heterocycles.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 3,3-Difluoro-4-Hydroxy-, 1,1-Dimethylethyl Ester
CAS No.	1209780-71-1
Molecular Formula	C11H19F2NO3
Molecular Weight	251.27 g/mol
Synonyms	3,3-Difluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate; N-Boc-3,3-difluoro-4-hydroxypiperidine; 1-Boc-3,3-difluoro-4-hydroxypiperidine; 3,3-Difluoro-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; Boc-3,3-difluoro-4-hydroxypiperidine; 3,3-Difluoro-4-hydroxy-N-Boc-piperidine
EINECS	Contact for details

Quality Control

Our 1-Piperidinecarboxylic Acid, 3,3-Difluoro-4-Hydroxy-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring material that meets ICH guidelines for impurity profiling and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.