Description

5-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Pyrazine-2-Carboxylic Acid is a high-purity, protected piperazine-pyrazine carboxylic acid derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceutical agents, particularly in medicinal chemistry programs targeting complex heterocyclic scaffolds. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of potential drug candidates, especially within kinase inhibitor and other targeted therapy discovery pipelines.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and protease inhibitor research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the piperazine-pyrazine pharmacophore.
• Peptidomimetic Synthesis: Serves as a carboxylic acid component for coupling reactions to create peptide-like molecules with enhanced metabolic stability.
• Chemical Biology Probes: Employed in the development of tool compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and niche target molecules.
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic and cross-coupling chemistry.

Basic Information

Item	Details
Product Name	5-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Pyrazine-2-Carboxylic Acid
CAS No.	1209646-17-2
Molecular Formula	C14H20N4O4
Molecular Weight	308.33 g/mol
Synonyms	5-[4-[(2-Methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]pyrazine-2-carboxylic acid; Boc-Pip-Pyrazine-COOH; tert-Butyl 4-(5-carboxypyrazin-2-yl)piperazine-1-carboxylate; 2-Pyrazinecarboxylic acid, 5-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-piperazinyl]-; 5-(1-Boc-piperazin-4-yl)pyrazine-2-carboxylic acid; 5-(N-Boc-piperazinyl)pyrazine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 5-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Pyrazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, NMR) are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.