Description

5-n-Boc-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrazine-2-Carboxylic Acid is a high-purity, protected heterocyclic carboxylic acid building block, essential for advanced pharmaceutical research and development. Its core value lies in serving as a critical synthetic intermediate for constructing complex molecules, particularly in medicinal chemistry for drug discovery programs targeting various therapeutic areas. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to develop new therapeutic agents.
• Peptidomimetic Synthesis: Serves as a constrained scaffold to mimic peptide structures, enhancing metabolic stability and bioavailability.
• Library Synthesis for High-Throughput Screening: Employed in the generation of diverse compound libraries for biological screening against novel targets.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant scale for potential API manufacturing.
• Chemical Biology Probes: Incorporated into molecular probes to study biological pathways and protein function.

Basic Information

Product Name	5-n-Boc-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrazine-2-Carboxylic Acid
CAS No.	1209492-73-8
Molecular Formula	C₁₃H₁₇N₃O₄
Molecular Weight	279.29 g/mol
Synonyms	5-[(tert-Butoxycarbonyl)amino]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid; 5-Boc-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid; tert-Butyl 2-(carboxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-5(1H)-carboxylate; 5-(tert-Butoxycarbonyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic Acid; Boc-protected THPP-2-COOH; CAS 1209492-73-8.
EINECS	Contact for details

Quality Control

Our 5-n-Boc-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.