Description

7-(tert-Butoxycarbonyl)-5,6,7,8-Tetrahydro-[1,2,4]Triazolo[1,5-A]Pyrazine-2-Carboxylic Acid CAS NO 1208928-62-4 is a high-purity, advanced pharmaceutical intermediate featuring a fused triazolopyrazine heterocyclic core protected by a tert-butoxycarbonyl (Boc) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry: Used as a versatile scaffold for constructing complex heterocyclic molecules in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of targeted protein degradation therapeutics.
• Kinase Inhibitor Synthesis: Employed in the construction of triazolopyrazine-based compounds targeting various kinase enzymes.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.

Basic Information

Product Name	7-(tert-Butoxycarbonyl)-5,6,7,8-Tetrahydro-[1,2,4]Triazolo[1,5-A]Pyrazine-2-Carboxylic Acid
CAS No.	1208928-62-4
Molecular Formula	C11H16N4O4
Molecular Weight	268.27 g/mol
Synonyms	Boc-THPTP-COOH; 1,2,4-Triazolo[1,5-a]pyrazine-2-carboxylic acid, 5,6,7,8-tetrahydro-7-[(1,1-dimethylethoxy)carbonyl]-; 7-Boc-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-2-carboxylic acid; tert-Butyl 2-(carboxymethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazine-7(8H)-carboxylate (tautomeric form); 7-(Boc)-5,6,7,8-tetrahydrotriazolopyrazine-2-carboxylic acid; 1208928-62-4; Boc-protected tetrahydrotriazolopyrazine carboxylic acid
EINECS	Contact for details

Quality Control

Our 7-(tert-Butoxycarbonyl)-5,6,7,8-Tetrahydro-[1,2,4]Triazolo[1,5-A]Pyrazine-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.