Description

1-Piperidinecarboxylic Acid, 3-Amino-4-Fluoro-, Phenylmethyl Ester, (3R,4R)-Rel- is a high-purity, stereochemically defined chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound is valued for its role as a key building block in the development of active pharmaceutical ingredients (APIs), particularly those targeting complex biological pathways. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutic agents, where precise molecular architecture is critical for efficacy.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of complex drug candidates, especially in medicinal chemistry research.
• API Development: Used as a building block for constructing the core scaffold of potential Active Pharmaceutical Ingredients (APIs) in discovery and process development.
• Protease Inhibitor Research: The piperidinecarboxylic acid structure suggests potential utility in the development of enzyme inhibitors, including protease and kinase inhibitors.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce the (3R,4R)-rel configuration into target molecules, ensuring high enantiomeric purity.
• Chemical Biology Probes: Can be utilized in the design and synthesis of molecular probes for studying biological mechanisms and target engagement.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis organizations (CSOs) and CDMOs (Contract Development and Manufacturing Organizations) serving the pharmaceutical industry.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 3-Amino-4-Fluoro-, Phenylmethyl Ester, (3R,4R)-Rel-
CAS No.	1207853-15-3
Molecular Formula	C13H17FN2O2
Molecular Weight	252.29 g/mol
Synonyms	Benzyl (3R,4R)-3-amino-4-fluoropiperidine-1-carboxylate; rel-(3R,4R)-Benzyl 3-amino-4-fluoropiperidine-1-carboxylate; (3R,4R)-rel-Benzyl 3-amino-4-fluoropiperidine-1-carboxylate; 3-Amino-4-fluoropiperidine-1-carboxylic acid benzyl ester, (3R,4R)-rel-; 1-N-Cbz-3-amino-4-fluoropiperidine, (3R,4R)-rel-; (R,R)-Benzyl 3-amino-4-fluoropiperidine-1-carboxylate (relative); 3-Amino-4-fluoro-1-piperidinecarboxylic acid phenylmethyl ester, (3R,4R)-rel-
EINECS	Contact for details

Quality Control

Our production of 1-Piperidinecarboxylic Acid, 3-Amino-4-Fluoro-, Phenylmethyl Ester, (3R,4R)-Rel- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized by advanced analytical techniques, including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.