Description

2-Ethynyl-5-Methylpyrazine is a specialized heterocyclic building block featuring a reactive ethynyl group. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working in medicinal chemistry and fine chemical synthesis. The compound, with CAS number 1207627-45-9, enables efficient cross-coupling and cycloaddition reactions to create novel molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, leveraging its pyrazine core for bioactivity.
• Material Science: Acts as a monomer or cross-linking agent in the development of advanced polymers and functional materials with specific electronic or optical properties.
• Ligand Synthesis: Employed in organometallic chemistry for the preparation of novel ligands used in catalysis.
• Flavor & Fragrance Chemistry: The methylpyrazine moiety is a known flavor component; derivatives are explored for creating novel aroma molecules.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting exploratory synthetic chemistry.

Basic Information

Product Name	2-Ethynyl-5-Methylpyrazine
CAS No.	1207627-45-9
Molecular Formula	C7H6N2
Molecular Weight	118.14 g/mol
Synonyms	5-Methyl-2-ethynylpyrazine; 2-Ethynyl-5-methyl-1,4-diazine; Ethynyl-5-methylpyrazine; 5-Methylpyrazin-2-ylacetylene; (5-Methylpyrazin-2-yl)ethyne
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-5-Methylpyrazine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, it is recommended to keep the material under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.