Description

tert-Butyl 5-Bromo-3-Hydroxypyridin-2-Ylcarbamate CAS NO 1207175-73-2 is a high-purity, advanced pharmaceutical intermediate characterized by its brominated pyridine core and carbamate protecting group. This compound is critical for enabling complex synthetic routes in medicinal chemistry, particularly for the development of targeted small-molecule therapeutics. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of novel drug candidates, especially within oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization to introduce specific bromine and hydroxyl functionalities.
• Kinase Inhibitor Synthesis: Serves as a precursor in the construction of complex heterocyclic scaffolds common in kinase inhibitor drug discovery programs.
• Chemical Biology Probes: Utilized for creating labeled or tagged molecular probes to study biological pathways and protein interactions.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Academic Research: Employed in university laboratories for methodological development and the exploration of new synthetic transformations involving halogenated pyridines.

Basic Information

Product Name	tert-Butyl 5-Bromo-3-Hydroxypyridin-2-Ylcarbamate
CAS No.	1207175-73-2
Molecular Formula	C10H13BrN2O3
Molecular Weight	289.13 g/mol
Synonyms	5-Bromo-3-hydroxy-2-pyridinecarboxylic acid tert-butyl carbamate; 2-((tert-Butoxycarbonyl)amino)-5-bromo-3-hydroxypyridine; tert-Butyl N-(5-bromo-3-hydroxypyridin-2-yl)carbamate; 2-((tert-Butoxycarbonyl)amino)-5-bromopyridin-3-ol; 5-Bromo-3-hydroxypyridine-2-carbamic acid tert-butyl ester; tert-Butyl (5-bromo-3-hydroxypyridin-2-yl)carbamate; BOC-5-Bromo-3-hydroxypyridin-2-amine
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Bromo-3-Hydroxypyridin-2-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for pharmaceutical R&D, ensuring reliable performance in your sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if possible to maintain long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.