Description

5-(Trifluoromethoxy)-2-Pyridinecarbonitrile is a high-value, multi-functional chemical intermediate featuring a pyridine core substituted with a trifluoromethoxy group and a nitrile functionality. This compound is prized for its role in facilitating the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique trifluoromethoxy moiety can significantly enhance metabolic stability and lipophilicity. It is an essential building block for researchers and manufacturers developing active pharmaceutical ingredients (APIs), crop protection agents, and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly for kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Serves as a critical precursor in the manufacture of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethoxy group.
• Ligand and Catalyst Development: Used in the design of specialized ligands for catalysis and in the synthesis of functional materials.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new chemical spaces and reaction pathways in medicinal and synthetic chemistry.
• Fluorinated Building Block: Provides a source of the trifluoromethoxy (OCF3) group, a valuable motif for modifying the physical and biological properties of target molecules.

Basic Information

Product Name	5-(Trifluoromethoxy)-2-Pyridinecarbonitrile
CAS No.	1206978-22-4
Molecular Formula	C7H3F3N2O
Molecular Weight	188.11 g/mol
Synonyms	2-Cyano-5-(trifluoromethoxy)pyridine; 5-(Trifluoromethoxy)picolinonitrile; 2-Pyridinecarbonitrile, 5-(trifluoromethoxy)-; 5-(Trifluoromethoxy)-2-cyanopyridine; 5-(Trifluoromethoxyl)picolinonitrile; 5-(Trifluoromethoxy)picolinonitrile; 5-OCF3-Picolinonitrile
EINECS	Contact for details

Quality Control

Every batch of 5-(Trifluoromethoxy)-2-Pyridinecarbonitrile is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure compliance with exacting purity standards and customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.