Description

4-(Difluoromethoxy)Pyridin-2-Amine is a specialized pyridine derivative featuring a difluoromethoxy substituent, which imparts unique electronic and steric properties to the molecule. This compound serves as a critical pharmaceutical intermediate and building block in advanced organic synthesis, enabling the development of novel active ingredients. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and material science industries seeking to incorporate fluorine-containing motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis, facilitating challenging chemical transformations.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals, organic semiconductors, and polymers with tailored electronic properties.
• Fluorine Chemistry Studies: Acts as a valuable substrate for investigating the effects of fluorine substitution on reaction kinetics, metabolic stability, and lipophilicity in medicinal chemistry programs.

Basic Information

Product Name	4-(Difluoromethoxy)Pyridin-2-Amine
CAS No.	1206972-19-1
Molecular Formula	C6H6F2N2O
Molecular Weight	160.12 g/mol
Synonyms	2-Amino-4-(difluoromethoxy)pyridine; 4-(Difluoromethoxy)-2-pyridinamine; 2-Pyridinamine, 4-(difluoromethoxy)-; 4-(Difluoromethoxy)pyridin-2-ylamine; 4-(Difluoromethoxy)-2-aminopyridine; 2-Amino-4-difluoromethoxypyridine; 4-Difluoromethoxypyridin-2-amine
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Pyridin-2-Amine is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.