Description

5-Bromo-3-Fluoro-2-(Hydroxymethyl)Pyridine is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine and fluorine substituents alongside a hydroxymethyl handle, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the halogenated pyridine core can impart specific biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Employed in the synthesis of functionalized polymers or organic electronic materials due to its modifiable pyridine ring.
• Chemical Biology Probes: Useful for creating tagged molecules or probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Bromo-3-Fluoro-2-(Hydroxymethyl)Pyridine
CAS No.	1206968-92-4
Molecular Formula	C6H5BrFNO
Molecular Weight	206.01 g/mol
Synonyms	2-(Hydroxymethyl)-5-bromo-3-fluoropyridine; 5-Bromo-3-fluoro-2-pyridinemethanol; (5-Bromo-3-fluoro-2-pyridinyl)methanol; 3-Fluoro-5-bromo-2-(hydroxymethyl)pyridine; 2-Pyridinemethanol, 5-bromo-3-fluoro-
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Fluoro-2-(Hydroxymethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO 9001 guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.