Description

4-(Benzyloxy)-3,3-Difluoropiperidine is a high-value, fluorinated piperidine derivative used as a critical building block in advanced organic synthesis. This compound matters for its role in introducing the difluoropiperidine moiety, a key structural feature known to enhance the metabolic stability, bioavailability, and binding affinity of target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of new active ingredients, including potential therapeutics for central nervous system disorders and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly for neurological and psychiatric targets.
• Agrochemical Synthesis: Used in creating advanced herbicide and pesticide candidates, where the fluorinated piperidine structure can improve efficacy and environmental profile.
• Medicinal Chemistry: Serves as a versatile scaffold for constructing compound libraries in drug discovery programs via parallel and combinatorial synthesis.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds or molecular probes for studying biological pathways and target engagement.
• Process Chemistry: Utilized in route scouting and scale-up optimization for the commercial production of fluorinated fine chemicals.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies involving fluorinated heterocycles.

Basic Information

Item	Detail
Product Name	4-(Benzyloxy)-3,3-Difluoropiperidine
CAS No.	1206540-59-1
Molecular Formula	C12H15F2NO
Molecular Weight	227.25 g/mol
Synonyms	3,3-Difluoro-4-(phenylmethoxy)piperidine; 4-(Benzyloxy)-3,3-difluoropiperidine; 3,3-Difluoropiperidin-4-yl benzyl ether; 1-Boc-4-(benzyloxy)-3,3-difluoropiperidine (protected form); 4-Benzyloxy-3,3-difluoropiperidine; 3,3-Difluoro-4-benzyloxypiperidine; 4-(Benzyloxy)-3,3-difluoropiperidine hydrochloride (salt form); 1206540-59-1
EINECS	Contact for details

Quality Control

Our 4-(Benzyloxy)-3,3-Difluoropiperidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (by HPLC), impurity profiles, and residual solvent content. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.