Description

2-Fluoro-3-Trifluoromethyl-Pyrazine is a high-value, multi-fluorinated heterocyclic building block essential for advanced chemical synthesis. This compound is prized for its ability to introduce both fluorine and a trifluoromethyl group, significantly altering the physicochemical properties of target molecules. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, enabling the development of novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral drug discovery.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine and trifluoromethyl groups improve biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and electronic materials with unique dielectric and surface properties.
• Fluorine Chemistry & Labeling: Acts as a versatile reagent for introducing 18F or 19F labels in positron emission tomography (PET) tracer development and NMR spectroscopy probes.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the life sciences sector.

Basic Information

Product Name	2-Fluoro-3-Trifluoromethyl-Pyrazine
CAS No.	1206524-60-8
Molecular Formula	C5H2F4N2
Molecular Weight	166.08 g/mol
Synonyms	3-Trifluoromethyl-2-fluoropyrazine; 2-Fluoro-3-(trifluoromethyl)pyrazine; Pyrazine, 2-fluoro-3-(trifluoromethyl)-; 1206524-60-8; FC-1133; FC1133; Fluorinated Pyrazine Derivative
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-3-Trifluoromethyl-Pyrazine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and commercial-scale synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.