Description

5-(Methoxycarbonyl)Pyrazine-2-Carboxylic Acid is a high-purity pyrazine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its bifunctional reactivity, offering both a carboxylic acid and a methyl ester group on a heterocyclic scaffold, which enables precise molecular construction. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and plant growth regulators that require pyrazine-based active ingredients.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating chelating ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science Research: Employed in the development of organic electronic materials, such as conductive polymers and molecular semiconductors.
• Chemical Biology Probes: Utilized as a core structure for designing fluorescent tags, enzyme inhibitors, and other biochemical tools for proteomics and diagnostics research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.

Basic Information

Item	Details
Product Name	5-(Methoxycarbonyl)Pyrazine-2-Carboxylic Acid
CAS No.	1206250-26-1
Molecular Formula	C8H6N2O4
Molecular Weight	194.15 g/mol
Synonyms	Methyl 5-carboxypyrazine-2-carboxylate; 2-Pyrazinecarboxylic acid, 5-(methoxycarbonyl)-; 5-Carboxy-2-pyrazinecarboxylic acid methyl ester; Pyrazine-2,5-dicarboxylic acid monomethyl ester; 5-Methoxycarbonylpyrazine-2-carboxylic acid; Methyl hydrogen pyrazine-2,5-dicarboxylate
EINECS	Contact for details

Quality Control

Our production of 5-(Methoxycarbonyl)Pyrazine-2-Carboxylic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including identity confirmation by spectroscopic methods (IR, NMR) and purity determination by HPLC. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key parameters such as assay, impurity profile, and residual solvents. Our quality system is designed to support development from research to commercial scale, with the capability to meet specific customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect purity and stability. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.