Description

2-Bromo-3,5-dichloropyrazine is a versatile halogenated pyrazine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is needed by research chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of complex heterocyclic cores found in drug candidates, particularly in kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the pyrazine scaffold's bioactivity.
• Material Science Research: Serves as a precursor for the synthesis of ligands, functionalized polymers, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of chemical probes.
• Cross-Coupling Reactions: The bromine and chlorine substituents make it an excellent substrate for sequential palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations.
• Nucleophilic Aromatic Substitution: The electron-deficient pyrazine ring facilitates selective displacement of halogens, enabling diverse functionalization.

Basic Information

Product Name	2-Bromo-3,5-dichloropyrazine
CAS No.	1206249-40-2
Molecular Formula	C4HBrCl2N2
Molecular Weight	227.87 g/mol
Synonyms	3,5-Dichloro-2-bromopyrazine; Pyrazine, 2-bromo-3,5-dichloro-; 2-Bromo-3,5-dichloro-pyrazine; 1206249-40-2; Bromodichloropyrazine
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,5-dichloropyrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be moisture-sensitive; store under an inert atmosphere if specified for high-purity grades.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.