Description

5-(4-Methoxy-Benzylamino)-Pyrazine-2-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its pyrazine core and methoxy-benzylamino substituent. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and novel drug candidates, offering a key building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers targeting therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Contract Manufacturing: Used by CDMOs (Contract Development and Manufacturing Organizations) for the production of high-value, small-molecule therapeutics under cGMP conditions.
• Academic & Institutional Research: Employed in university and institutional labs for the development of new synthetic methodologies and bio-active compounds.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.

Basic Information

Product Name	5-(4-Methoxy-Benzylamino)-Pyrazine-2-Carboxylic Acid Methyl Ester
CAS No.	1204527-84-3
Molecular Formula	C15H17N3O3
Molecular Weight	287.31 g/mol
Synonyms	Methyl 5-[(4-methoxyphenyl)methylamino]pyrazine-2-carboxylate; 5-[(4-Methoxybenzyl)amino]pyrazine-2-carboxylic acid methyl ester; 5-(4-Methoxybenzylamino)pyrazine-2-carboxylic Acid Methyl Ester; 1204527-84-3; 5-(p-Methoxybenzylamino)pyrazine-2-carboxylic acid methyl ester; Methyl 5-(4-methoxybenzylamino)pyrazine-2-carboxylate
EINECS	Contact for details

Quality Control

Our 5-(4-Methoxy-Benzylamino)-Pyrazine-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP requirements. Specifications are aligned with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.