Description

(R)-1-Boc-3-n-(Pyridin-4-Ylmethyl)-Amino-Pyrrolidine is a high-purity, chiral pyrrolidine derivative that serves as a critical building block in modern organic synthesis. Its value lies in its role as a sophisticated intermediate for constructing complex molecules with defined stereochemistry, essential for developing active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutics, particularly in areas requiring advanced chiral amines.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• Asymmetric Synthesis: Used as a ligand or organocatalyst precursor in stereoselective chemical transformations.
• Peptidomimetics & PROTACs: Incorporated into the backbone of peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) to modulate biological activity and pharmacokinetics.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes to study enzyme function and protein-protein interactions.
• Agrochemical Research: Utilized in the synthesis of advanced, chiral active ingredients for crop protection.
• Material Science: Potential monomer or additive for creating specialized polymers with unique properties.

Basic Information

Product Name	(R)-1-Boc-3-n-(Pyridin-4-Ylmethyl)-Amino-Pyrrolidine
CAS No.	1204421-49-7
Molecular Formula	C16H25N3O2
Molecular Weight	291.39 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-3-[(pyridin-4-ylmethyl)amino]pyrrolidine; (R)-N-[(Pyridin-4-yl)methyl]-1-Boc-3-aminopyrrolidine; tert-Butyl (3R)-3-[(pyridin-4-ylmethyl)amino]pyrrolidine-1-carboxylate; (R)-1-Boc-3-((pyridin-4-ylmethyl)amino)pyrrolidine; (R)-N1-Boc-3-(4-Picolylamino)pyrrolidine; (R)-3-(4-Pyridylmethylamino)-1-Boc-pyrrolidine; (R)-1-Boc-3-(4-Pyridylmethylamino)pyrrolidine; (R)-tert-Butyl 3-((pyridin-4-ylmethyl)amino)pyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-3-n-(Pyridin-4-Ylmethyl)-Amino-Pyrrolidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and standard pharmacopeial identification methods. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided and available upon request, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for prolonged periods to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.