Description

2-Chloro-4-(Difluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and difluoromethyl substituents, makes it an essential intermediate for introducing specific pharmacophores and agrochemical motifs. This compound is primarily sought after by R&D and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Research & Development: A versatile reagent for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution, enabling the construction of complex molecular architectures.
• Fluorine Chemistry: Valuable synthon for introducing fluorine-containing groups into target molecules, leveraging the reactivity of the difluoromethyl moiety.

Basic Information

Product Name	2-Chloro-4-(Difluoromethyl)Pyridine
CAS No.	1204296-03-6
Molecular Formula	C6H4ClF2N
Molecular Weight	163.55 g/mol
Synonyms	2-Chloro-4-(difluoromethyl)pyridine; 4-(Difluoromethyl)-2-chloropyridine; 2-Chloro-4-difluoromethylpyridine; Pyridine, 2-chloro-4-(difluoromethyl)-; 1204296-03-6; 2-Chloro-4-(difluoromethyl)pyridine (CAS 1204296-03-6)
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Difluoromethyl)Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data including HPLC/GC purity, identity confirmation by NMR and IR spectroscopy, and residual solvent analysis. A detailed Certificate of Analysis (COA) is supplied with each batch, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for prolonged storage or when opening containers to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.