Description

3-(2-Chloro-5-Methylpyridin-3-Yl)Prop-2-Yn-1-Ol is a high-purity, functionalized pyridine derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate, enabling the construction of complex molecular architectures with precision. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, including herbicides and fungicides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis due to its propargylic alcohol and pyridine functionalities.
• Material Science Research: Employed in the synthesis of functional organic materials, such as conductive polymers or metal-organic frameworks (MOFs), where its structural motifs can impart specific electronic properties.
• Chemical Biology Probes: Utilized as a building block for synthesizing molecular probes and tags used in bio-conjugation and target identification studies.

Basic Information

Product Name	3-(2-Chloro-5-Methylpyridin-3-Yl)Prop-2-Yn-1-Ol
CAS No.	1203499-49-3
Molecular Formula	C9H8ClNO
Molecular Weight	181.62 g/mol
Synonyms	3-(2-Chloro-5-methylpyridin-3-yl)prop-2-yn-1-ol; 2-Chloro-5-methyl-3-(2-propyn-1-yloxy)pyridine; 3-(2-Chloro-5-methyl-3-pyridinyl)-2-propyn-1-ol; Propargyl alcohol, 3-(2-chloro-5-methyl-3-pyridinyl)-; 2-Propyn-1-ol, 3-(2-chloro-5-methyl-3-pyridinyl)-; 1203499-49-3; 3-(2-Chloro-5-methylpyridin-3-yl)propiolic alcohol
EINECS	Contact for details

Quality Control

Our 3-(2-Chloro-5-Methylpyridin-3-Yl)Prop-2-Yn-1-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance in cGMP and ISO 9001 environments for research and commercial-scale applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.