Description

6-Ethynylfuro[3,2-B]Pyridine CAS NO 1203499-35-7 is a high-purity, advanced heterocyclic building block featuring a fused furopyridine core with a terminal ethynyl group. This compound is of significant value in pharmaceutical research and development, serving as a key synthetic intermediate for constructing complex molecular architectures. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications in drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its versatile ethynyl handle for click chemistry and cross-coupling reactions.
• Agrochemical Research: Serves as a precursor in the development of new crop protection agents and herbicides.
• Material Science: Potential monomer or precursor for constructing organic electronic materials, such as organic semiconductors or metal-organic frameworks (MOFs).
• Chemical Biology: Employed as a probe or linker in bioconjugation and labeling strategies for target identification and validation.
• Process Chemistry: Used in scaling up synthetic routes for commercial production of complex molecules.

Basic Information

Product Name	6-Ethynylfuro[3,2-B]Pyridine
CAS No.	1203499-35-7
Molecular Formula	C9H5NO
Molecular Weight	143.14 g/mol
Synonyms	6-Ethynylfuro[3,2-b]pyridine; Furo[3,2-b]pyridine, 6-ethynyl-; 6-Ethynylfuro(3,2-b)pyridine; 6-Ethynyl-2,3-dihydrofuro[3,2-b]pyridine (precursor/related); 6-Ethynyl-2,3-dihydrofuro[3,2-b]pyridin-3-ol (related); 6-Ethynyl-3-hydroxy-2,3-dihydrofuro[3,2-b]pyridine (related)
EINECS	Contact for details

Quality Control

Every batch of 6-Ethynylfuro[3,2-B]Pyridine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles via validated methods (HPLC, GC, NMR) is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.